{
  "_id": "6aafc5923d719c1f84081cbf",
  "Package": "RLescalation",
  "Type": "Package",
  "Title": "Optimal Dose Escalation Using Deep Reinforcement Learning",
  "Version": "1.0.3",
  "Authors@R": "c(\nperson(\"Kentaro\", \"Matsuura\", , \"matsuurakentaro55@gmail.com\",\nrole = c(\"aut\", \"cre\", \"cph\"), comment = c(ORCID = \"0000-0001-5262-055X\")))",
  "Description": "An implementation to compute an optimal dose escalation\nrule using deep reinforcement learning in phase I oncology\ntrials (Matsuura et al. (2023)\n<doi:10.1080/10543406.2023.2170402>). The dose escalation rule\ncan directly optimize the percentages of correct selection\n(PCS) of the maximum tolerated dose (MTD).",
  "URL": "https://github.com/MatsuuraKentaro/RLescalation",
  "BugReports": "https://github.com/MatsuuraKentaro/RLescalation/issues",
  "VignetteBuilder": "knitr",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "Language": "en-US",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.2",
  "Collate": "'timer.R' 'train_algo.R' 'utils.R' 'escalation_rule.R'\n'rl_dnn_config.R' 'rl_config_set.R' 'compute_rl_scenarios.R'\n'learn_escalation_rule.R' 'setup_python.R' 'zzz.R'\n'simulate_one_trial.R'",
  "Config/pak/sysreqs": "libpng-dev python3",
  "Repository": "https://matsuurakentaro.r-universe.dev",
  "Date/Publication": "2025-10-07 13:27:23 UTC",
  "RemoteUrl": "https://github.com/matsuurakentaro/rlescalation",
  "RemoteRef": "HEAD",
  "RemoteSha": "11151fdc2d24da7a5071418f6c64caf323930d81",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-09-20 11:34:51 UTC",
    "User": "root"
  },
  "Author": "Kentaro Matsuura [aut, cre, cph] (ORCID:\n<https://orcid.org/0000-0001-5262-055X>)",
  "Maintainer": "Kentaro Matsuura <matsuurakentaro55@gmail.com>",
  "_user": "matsuurakentaro",
  "_type": "src",
  "_file": "RLescalation_1.0.3.tar.gz",
  "_fileid": "https://r2.ropensci.org/b6ea0d3cd904b390ec5c71fec49b3e2156daf3297b02b5d883b7a6ddde389426",
  "_filesize": 191969,
  "_sha256": "b6ea0d3cd904b390ec5c71fec49b3e2156daf3297b02b5d883b7a6ddde389426",
  "_expires": "2026-12-29T11:37:52.000Z",
  "_created": "2026-09-20T11:34:51.000Z",
  "_published": "2026-09-20T11:37:54.691Z",
  "_jobs": [
    {
      "job": 106071564439,
      "time": 148,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "10604433008"
    },
    {
      "job": 106071564424,
      "time": 125,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10604278391"
    },
    {
      "job": 106071564533,
      "time": 75,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "10604901887"
    },
    {
      "job": 106071564453,
      "time": 99,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10604298333"
    },
    {
      "job": 106071205719,
      "time": 181,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10604332960"
    },
    {
      "job": 106071564412,
      "time": 135,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "10604677582"
    },
    {
      "job": 106071564447,
      "time": 62,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "10604717491"
    },
    {
      "job": 106071564449,
      "time": 67,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "10604557785"
    },
    {
      "job": 106071564521,
      "time": 64,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "10604233611"
    }
  ],
  "_host": "GitHub-Actions",
  "_buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345",
  "_status": "success",
  "_upstream": "https://github.com/matsuurakentaro/rlescalation",
  "_commit": {
    "id": "11151fdc2d24da7a5071418f6c64caf323930d81",
    "author": "Kentaro Matsuura <matsuurakentaro55@gmail.com>",
    "committer": "Kentaro Matsuura <matsuurakentaro55@gmail.com>",
    "message": "for CRAN update\n",
    "time": 1759843643
  },
  "_maintainer": {
    "name": "Kentaro Matsuura",
    "email": "matsuurakentaro55@gmail.com",
    "login": "matsuurakentaro",
    "twitter": "@hankagosa",
    "description": "Email: matsuurakentaro55[at]gmail.com",
    "uuid": 11885625,
    "orcid": "0000-0001-5262-055X"
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "glue",
      "role": "Imports"
    },
    {
      "package": "R6",
      "role": "Imports"
    },
    {
      "package": "nleqslv",
      "role": "Imports"
    },
    {
      "package": "reticulate",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "zip",
      "role": "Imports"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    }
  ],
  "_owner": "matsuurakentaro",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-41",
      "n": 1
    }
  ],
  "_tags": [
    {
      "name": "v1.0.3",
      "date": "2025-10-07"
    }
  ],
  "_stars": 2,
  "_contributors": [
    {
      "user": "matsuurakentaro",
      "count": 13,
      "uuid": 11885625
    }
  ],
  "_userbio": {
    "uuid": 11885625,
    "type": "user",
    "name": "Kentaro Matsuura",
    "followers": 142,
    "description": "Email: matsuurakentaro55[at]gmail.com"
  },
  "_downloads": {
    "count": 222,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/RLescalation"
  },
  "_devurl": "https://github.com/matsuurakentaro/rlescalation",
  "_searchresults": 0,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/RLescalation.html",
    "LICENSE"
  ],
  "_homeurl": "https://github.com/matsuurakentaro/rlescalation",
  "_realowner": "matsuurakentaro",
  "_cranurl": true,
  "_releases": [
    {
      "version": "1.0.1",
      "date": "2025-01-09"
    },
    {
      "version": "1.0.2",
      "date": "2025-02-08"
    },
    {
      "version": "1.0.3",
      "date": "2025-10-07"
    }
  ],
  "_exports": [
    "clean_python_settings",
    "compute_rl_scenarios",
    "EscalationRule",
    "learn_escalation_rule",
    "rl_config_set",
    "rl_dnn_config",
    "setup_python",
    "simulate_one_trial"
  ],
  "_help": [
    {
      "page": "clean_python_settings",
      "title": "Clean the Python Virtual Environment",
      "topics": [
        "clean_python_settings"
      ]
    },
    {
      "page": "compute_rl_scenarios",
      "title": "Compute DLT Probability Scenarios for Reinforcement Learning",
      "topics": [
        "compute_rl_scenarios"
      ]
    },
    {
      "page": "EscalationRule",
      "title": "EscalationRule Class",
      "topics": [
        "EscalationRule"
      ]
    },
    {
      "page": "learn_escalation_rule",
      "title": "Build an Optimal Dose Escalation Rule using Reinforcement Learning",
      "topics": [
        "learn_escalation_rule"
      ]
    },
    {
      "page": "rl_config_set",
      "title": "Configuration of Reinforcement Learning",
      "topics": [
        "rl_config_set"
      ]
    },
    {
      "page": "rl_dnn_config",
      "title": "DNN Configuration for Reinforcement Learning",
      "topics": [
        "rl_dnn_config"
      ]
    },
    {
      "page": "setup_python",
      "title": "Setting up a Python Virtual Environment",
      "topics": [
        "setup_python"
      ]
    },
    {
      "page": "simulate_one_trial",
      "title": "Simulate One Trial Using an Obtained Optimal Dose Escalation Rule",
      "topics": [
        "simulate_one_trial"
      ]
    }
  ],
  "_pkglogo": "https://github.com/matsuurakentaro/rlescalation/raw/HEAD/man/figures/logo.png",
  "_readme": "https://github.com/matsuurakentaro/rlescalation/raw/HEAD/README.md",
  "_rundeps": [
    "cli",
    "glue",
    "here",
    "jsonlite",
    "lattice",
    "Matrix",
    "nleqslv",
    "png",
    "R6",
    "rappdirs",
    "Rcpp",
    "RcppTOML",
    "reticulate",
    "rlang",
    "rprojroot",
    "withr",
    "zip"
  ],
  "_vignettes": [
    {
      "source": "RLescalation.Rmd",
      "filename": "RLescalation.html",
      "title": "Optimal Dose Escalation Using Deep Reinforcement Learning",
      "author": "Kentaro Matsuura",
      "engine": "knitr::rmarkdown",
      "headings": [
        "RLescalation",
        "Overview",
        "Installation",
        "Example",
        "Learn a dose escalation rule",
        "How to use the escalation rule",
        "How to evaluate the escalation rule",
        "Tips",
        "Custom scenarios for reinforcement learning",
        "What to do if the learning is unstable",
        "How to use Escalation Rule Class",
        "Save the escalation rule",
        "Inputs of learn_escalation_rule function",
        "Obtain returns during reinforcement learning",
        "Resume learning",
        "Use checkpoint"
      ],
      "created": "2024-12-31 08:16:05",
      "modified": "2025-02-10 14:11:55",
      "commits": 8
    }
  ],
  "_score": 4,
  "_indexed": true,
  "_nocasepkg": "rlescalation",
  "_universes": [
    "matsuurakentaro"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.0.3",
      "date": "2026-09-20T11:37:21.000Z",
      "distro": "resolute",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/d8db7a6156b9ededa8f5d9e7dc76746e313abf21ddd0269f3458e897ebf0a9a0",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "1.0.3",
      "date": "2026-09-20T11:37:18.000Z",
      "distro": "resolute",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/6aada78417b8108550e473c3c5025a45528bf362280dbf4f4d27f88cf2bc6dea",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.0.3",
      "date": "2026-09-20T11:36:14.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/da2122e9d148e697193b885cbaf3856b142aff0959344ffdb7c5695073b2cf6f",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "1.0.3",
      "date": "2026-09-20T11:36:37.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/b22e1fdd5b734e19b61c0c9008d8c99a9ed4733e9ce298e3eb30e522dbb7f0e4",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.0.3",
      "date": "2026-09-20T11:37:20.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/cd377eff43d7da3e054478d220e134d3c2c9d4ac2d84b9a616ce9e16592f9672",
      "status": "success",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.0.3",
      "date": "2026-09-20T11:35:50.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/677f4eb8bb5ec4a53030feff5c85da3b02b9976b1ec99db2d2d5aff6ed4290d3",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.0.3",
      "date": "2026-09-20T11:35:57.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/5d43253e991ef75c30bc6a83cd7e89d0e3d3a0e444b34eb4da0980c6beff0b34",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "1.0.3",
      "date": "2026-09-20T11:35:55.000Z",
      "commit": "11151fdc2d24da7a5071418f6c64caf323930d81",
      "fileid": "https://r2.ropensci.org/f5b73b7aea1e5fca3275793e1d3ead3fff274c3897bfe08699cd5ed42b1d95fe",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/matsuurakentaro/actions/runs/35508090345"
    }
  ]
}